Modeling Protein-RNA Interactions

aaRNA is an RNA binding site predictor using various features that out-performs sequence- or structure-only predictors.

Sequence-based predictors are usually shortsighted, due their fragmented view of a binding site. By contrast, structure-based predictors can reach higher specificity but usually at a cost of sensitivity.

As a consequence of these trade-offs, we aimed to develop a method that can optimally utilize both sequence and structural features for RNA-binding sites prediction.

How does aaRNA work?

The aaRNA server requires sequences to be input in FASTA format. Structures can be input as PDB identifiers or as user-provided structures in PDB format. Click here for more details.

To give you an overview of how this software works, check out the following results: example1 example2